I read this awesome manuscript, where the plot, pacing, and characters melted together taking the reader for an incredible ride. I loved it! Except, my agent told me that the topic is too taboo and she won’t be able to sell it to editors, not without having the author rewrite the offending part. Unfortunately, that will require a huge amount of work, possibly a complete overhaul.
So here’s the sad truth, do not write about topics that make people say “ick”. You know what they are. Very few people can pull off a Flowers in the Attic story. And my advice is don’t even get close to the edge.